(Human) Hepatitis C virus continues to represent one of the most significant threats to human health.
Although Hepatitis C Virus was discovered more than 20 years ago, its origins remain obscure and, until very recently, (Human) Hepatitis C Virus was considered the only member of the genus hepacivirus (a name concocted from words ‘hepatitis’, ‘c’ and ‘virus’).
, horses (Equine Hepatitis C Virus), bats (GB Virus-B), African Cattle (Bovine Hepatitis C Virus) and some rodents (Murine Hepatitis C Virus). This indicates a widespread distribution of hepaciviruses among animals.
Recently, yet another a novel species within the genus Hepacivirus was discovered in domestic cattle in northern Germany. Of the 158 investigated cattle herds in Germany 3,2% were positive for bovine hepacivirus.
Clinical and postmortem examination revealed no signs of disease, including liver damage.
 Kapoor et al: Characterization of a canine homolog of hepatitis C virus in Proceedings of the National Academy of Sciences - 2011
 Quan et al: Bats are a major natural reservoir for hepaciviruses and pegiviruses in Proceedings of the National Academy of Sciences - 2013
 Drexler et al: Evidence for novel hepaciviruses in rodents in PLoS Pathogens - 2013
 Bächlein et al: Identification of a Novel Hepacivirus in Domestic Cattle from Germany in Journal of Virology – 2015